Rapid reductive-carboxylation of secondary amines, one pot synthesis of N'-(4-11C-methyl)imipramine.
نویسندگان
چکیده
A new rapid high yield synthesis of radiolabeled N'-(4-11C-methyl)imipramine has been developed using a reductive-carboxylation approach, in which 11CO2 is reacted with either N'-trimethylsilyldesimipramine or N'-lithium derivative of desimipramine, followed by lithium aluminum hydride reduction, to give no carrier added or carrier added 11C-labeled imipramine respectively. The final product is characterized by chromatographic and spectroscopic methods.
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ورودعنوان ژورنال:
- International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
دوره 37 5 شماره
صفحات -
تاریخ انتشار 1986